Effect of prophylactic intravenous immunoglobulin on the frequency of infections in chronic lymphocytic leukemia Kronik lenfositik losemide profilaktik intravenoz immunglobulin kullaniminin enfeksiyon sikligina etkisi
Cerrahpasa Tip Dergisi, cilt.28, sa.2, ss.95-98, 1997 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 1997
- Dergi Adı: Cerrahpasa Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.95-98
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Background and Design. Infections are responsible from the majority of disease-related deaths in patients with chronic lymphocytic leukemia (CLL). Hypogammaglobulinemia is the most important cause of increased susceptibility to infections in this disease. Intravenous immunoglobulin (IVIG) is becoming an important adjunct to the prophylaxis and therapy of infections in CLL. Five patients with Rai stage III-IV CLL, and with frequent and severe infections, who where treated with 3 courses of IVIG (300 mg/kg, every three weeks) prophylactically are presented. Results. IgG levels increased in all patients after IVIG treatment. No infections were observed during treatment and in the follow-up period, except one episode of infection in one patient. Conclusion. IVIG treatment is effective in reducing the frequency of infections in CLL; but, regarding the expense of the therapy, it should be reserved for selected patients who develop frequent, severe and life-threatening infections.