Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population.

Kocak B., Saribas S., Demiryas S., Yilmaz E., Uysal Ö., Kepil N., ...Daha Fazla

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, cilt.82, ss.104288, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.meegid.2020.104288
  • Dergi Adı: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.104288
  • Anahtar Kelimeler: H. pylori, CagL, HLA, CagA, gastric cancer, duodenal ulcer, HUMAN-LEUKOCYTE ANTIGEN, CHRONIC ATROPHIC GASTRITIS, IV SECRETION, EPITHELIAL-CELLS, INFECTION, EXPRESSION, GENOTYPES, CARCINOMA, INTEGRIN, DISEASE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Colonization of the human gastric mucosa by H. pylori may cause peptic and duodenal ulcers (DUs), gastric lymphomas, and gastric cancers. The cagL gene is a component of cag T4SS and is involved in cagA translocation into host. An association between the risk of gastric cancer and the type of HLA class II (DR and/or DQ) was suggested in different populations. The aim of this study was to investigate, the clinical association of the cagL gene with host HLA alleles in H. pylori strains that were isolated from patients with gastric cancer, DU, and non-ulcer dyspepsia (NUD) and to determine the HLA allele that confers susceptibility or resistance for the risk of gastric cancer and DU development in Turkish patients.