An ultrasensitive '' OFF-ON '' fluorogenic sensor based on thiazole derivative for Zn2+: Food supplement, water and bio-imaging applications

Aydin D., Elmas Ş. N., Savran T., Arslan F. N., Sadi G., Yilmaz I.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, cilt.419, 2021 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 419
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jphotochem.2021.113459
  • Dergi Adı: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, Chimica, INSPEC
  • Anahtar Kelimeler: Zinc, Fluorescence sensor, Thiazol, Water, Food supplement, Living-cell, SCHIFF-BASE, FLUORESCENT SENSOR, CRYSTAL-STRUCTURE, METAL-COMPLEXES, ZN(II), PROBE, CHEMOSENSOR, LIGAND
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

In the present study, the design of a novel turn-on fluorescent probe ((E)-5-methoxy-4-((thiazol-2-ylimino)methyl)benzene-1,3-diol) (TBD) was reported. TBD showed an excellent fluorogenic response (lambda(ex) = 420 nm, lambda(em) = 530 nm) to sense Zn2+ in HEPES buffer/MeCN (5/95, v/v; pH = 7.4) media. The quantum (Phi) yield of the probe TBD increased importantly with Zn2+ and was calculated for TBD (Phi = 0.073) and TBD-Zn2+ complex (Phi = 0.78). The LOD and binding constant (Ka) of TBD were 1.29 nM and 1.102 x 10(6) M-1, respectively. The sensing process of TBD toward Zn2+ (1:1) was verified by the Job's plot, MALDI-TOF-MS, and H-1 NMR titration studies. The ''off-on'' fluorogenic response of TBD was qualified to the photo-induced electron transfer (PET) process. The experimental outcomes were also verified by theoretical DFT studies. Furthermore, TBD had been successfully utilized to detect Zn2+ in food supplement products, drinkable water samples and living-cells for on-site analysis.