Akademik Veri Yönetim Sistemi
Neurology Psychiatry and Brain Research, cilt.14, sa.3, ss.115-118, 2007 (SCI-Expanded, Scopus)
Objective: Risperidone, which is an atypical antipsychotic, is widely used in treating children and adolescents with many psychiatric disorders. Despite widespread clinical use, the safety of risperidone is a matter of concern for child psychiatrists. The aim of this study is to explore the supraventricular cardiac effects of risperidone. Methods: 34 patients who were diagnosed as mental retardation, attention deficit hyperactivity disorder or pervasive developmental disorder according to the DSM-IV criteria were included in this study. Risperidone treatment was initiated for the behavioral problems. Baseline biochemical parameters were assessed. The ECG records were obtained while patients were drug naive and two weeks after 0.25-1.0 mg/day risperidone intake. Measurement of P wave duration was carried out manually using a caliper. The difference between the P maximum (Pmax) and P minimum (Pmin) wave duration was calculated from the 12-lead ECG and was defined as the PWD. The data was analyzed using SPSS for Windows version 13.0. Results: Of 34 patients, aged 4-14 years, 6 were female and 28 were male. The weight of the patients was between 12-42 kg. The received dose of risperidone was between 0.25-1 mg/day. After treatment with risperidone for two weeks, ECGs of patients were compared with baseline ECGs. The differences between baseline and after risperidone therapy among PWD, Pmax, Pmin were statistically insignificant (p>0.05). The ECG variables in patients and healthy group were compared. In addition, there were no significant correlations between age, weight, received dose of risperidone and ECG variables in both patients and controls (p>0.05). Conclusion: Our study shows that risperidone may not influence atrial myocardial conduction in children with various psychiatric disorders at least in doses between 0.25-1.0 mg/day. Although the clinical importance of P wave measurements is unclear, our study is important that is investigating the influences of risperidone on atrial conduction. Further studies with larger sample size and higher doses of risperidone or comparing other atypical antipsychotic drugs with risperidone would be more explanatory. © Universitätsverlag Ulm GmbH 2007.