AR-A014418 as a glycogen synthase kinase-3 inhibitor: anti-apoptotic and therapeutic potential in experimental spinal cord injury.

Tunçdemir, MATEM; Yıldırım, Aziz; Karaoglan, Alper; Akdemir, Osman; Özturk, MELEK

doi:10.1016/j.neucir.2011.12.006

AR-A014418 as a glycogen synthase kinase-3 inhibitor: anti-apoptotic and therapeutic potential in experimental spinal cord injury.

Tunçdemir M., Yıldırım A., Karaoglan A., Akdemir O., Özturk M.

Neurocirugia (Asturias, Spain), cilt.24, ss.22-32, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.neucir.2011.12.006
Dergi Adı: Neurocirugia (Asturias, Spain)
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.22-32
Anahtar Kelimeler: Spinal cord injury, GSK-3beta, AR-A014418, Apoptosis, TGF-beta, GROWTH-FACTOR-BETA, SECONDARY DAMAGE, CELL-DEATH, STEM-CELLS, RATS, IMPROVES, TRAUMA, OLIGODENDROCYTES, DEGENERATION, PATHOGENESIS
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Objectives: We aimed to investigate the effects of AR-A014418, a strong inhibitor specific to GSK-3beta, on neuronal apoptosis and neuroprotection in the traumatic SCI model.