New 6-(4-bromophenyl)imidazo[2,1-b]thiazole derivatives: Synthesis and antimicrobial activity

Ulusoy N., Kiraz M., Kucukbasmaci Ö.

MONATSHEFTE FUR CHEMIE, cilt.133, sa.10, ss.1305-1315, 2002 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 133 Sayı: 10
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/s007060200108
  • Dergi Adı: MONATSHEFTE FUR CHEMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.1305-1315
  • Anahtar Kelimeler: imidazo[2,1-b]thiazole, 4-thiazolidinones, antibacterial activity, antifungal activity, antimycobacterial activity, IMIDAZO<2,1-B>THIAZOLE DERIVATIVES, THIAZOLIDINONE DERIVATIVES, ANTICONVULSANT ACTIVITY, HETEROCYCLIC-SYSTEMS, ANTIFUNGAL ACTIVITY, NITROGEN ATOM, 4-THIAZOLIDINONES, SUSCEPTIBILITY
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

New 4-alkyl/aryl-1-((6-(4-bromophenyl)-imidazo[2,1-b]thiazol-3-yl)-acetyl)-3-thiosemicarbazides and 3-alkyl/aryl-2-(((6-(4-bromophenyl)-imidazo[2,1-b]thiazol-3-yl)-acetyl)-hydrazono)4-thiazolidinones were synthesized from 6-(4-bromophenyl)-imidazo [2,1-b] thiazole-3-acetic acid hydrazide. Their structures were elucidated by elemental analyses and spectroscopic data. All compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H(37)Rv (ATCC 27294); they exhibited varying degrees of inhibition in the in vitro primary screening at 6.25 mug(.)cm(-3). The most active compound was 3-(4-nitrophenyl)-2-(((6-(4-bromophenyl)-imidazo[2,1-b]thiazol-3-yl)-acetyl)hydrazono)-4-thiazolidinone.