Akademik Veri Yönetim Sistemi
5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022), Ankara, Türkiye, 23 - 25 Kasım 2022, ss.157, (Özet Bildiri)
Model of the Future for Angiogenesis Assessment; Zebrafish
Şima KILIÇ1* (ORCID: https://orcid.org/0000-0002-3768-1589), Ayça Üvez2 (ORCID: https://orcid.org/0000-0002- 3875-2465), Elif İlkay ARMUTAK2 (ORCID: https://orcid.org/0000-0002-7359-6568) *1İstanbul University-Cerrahpaşa, Instute of Nanotechnology and Biotechnology, Department of Biotechnology, İstanbul, Turkey. 2 İstanbul University-Cerrahpaşa, Faculty of Veterinary Medicine, Department of Histology and Embriyology, İstanbul, Turkey.
*Corresponding author e-mail: sima@iuc.edu.tr
Abstract
Angiogenesis; it is necessary in tumor development and progression, as well one of the most important events is happened in the neoplastic process. Angiogenesis involves the formation of new microvessels in the body. It occurs physiologically or pathologically, depending on the endothelial cell proliferation in capillaries (1). While during the wound healing, physiologically angiogenesis takes a week or more, pathological angiogenesis may continue for months or years. Having a tumor with angiogenic features; it gaves an agresive behaviours and causes faster growth, higher invasion, and faster formation of metastases (2). Cancer is a fatal disease that still has no effective treatment and a high mortality rate. Recent studies are being done for developing a new cure of cancer and a wide variety of in vivo models are used. However, due to the fact that in vivo models give outcomes late and have more difficult working process, there has been a high interest in zebrafish models in the world. Zebrafish and human genomes share around 70% homology. Moreover, 82% of morbidity-associated genes in human have been linked to at least one ortholog in the zebrafish (3). These similarities support the relevance of the model, moreover the advantages of zebrafish are practical. The zebrafish is a small organism and requireslessinfrastructure and nursing than mammalian modelssuch asrodents (4). These features make the zebrafish model attractive for researchers and further studies. In addition to its resemblance to the human organism, the zebrafish model gaves opportunity to easily observe embryogenesis processes via ex utero embryo development and transparent structure during the first period of their life. As a conclusion; Zebrafish is a promising new model for today's research, as it has both economical and easier production conditions and gives fastly outcomes in angiogenesis models.
Keywords: Angiogenesis, Zebrafish, Cancer, In vivo