Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome

Lebrun-Frenay, Christine; Rollot, Fabien; Mondot, Lydiane; Zephir, Helene; Louapre, Celine; Le Page, Emmanuelle; Durand-Dubief, Francoise; Labauge, Pierre; Bensa, Caroline; Thouvenot, Eric; Laplaud, David; de Seze, Jerome; Ciron, Jonathan; Bourre, Bertrand; Cabre, Philippe; Casez, Olivier; Ruet, Aurelie; Mathey, Guillaume; Berger, Eric; Moreau, Thibault; Al Khedr, Abdulatif; Derache, Nathalie; Clavelou, Pierre; Guennoc, Anne-Marie; Creange, Alain; Neau, Jean-Philippe; Tourbah, Ayman; Camdessanche, Jean-Philippe; Maarouf, Adil; Callier, Celine; Vermersch, Patrick; Kantarci, Orhun; SİVA, AKSEL; Azevedo, Christina; Makhani, Naila; Cohen, Mikael; Pelletier, Daniel; Okuda, Darin; Vukusic, Sandra

doi:10.1001/jamanetworkopen.2021.28271

Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome

Lebrun-Frenay C., Rollot F., Mondot L., Zephir H., Louapre C., Le Page E., ...More

JAMA NETWORK OPEN, vol.4, no.10, 2021 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 4 Issue: 10
Publication Date: 2021
Doi Number: 10.1001/jamanetworkopen.2021.28271
Journal Name: JAMA NETWORK OPEN
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
Istanbul University-Cerrahpasa Affiliated: No

Abstract

IMPORTANCE Younger age, oligoclonal bands, and infratentorial and spinal cord lesions are factors associated with an increased 10-year risk of clinical conversion from radiologically isolated syndrome (RIS) to multiple sclerosis (MS). Whether disease-modifying therapy is beneficial for individuals with RIS is currently unknown.