A case of severe DRESS syndrome treated with therapeutic plasma exchange and intravenous immunoglobulin therapy

DURAK C., AYDEMİR S., Varol F., AYGÜN F., ÇOKUĞRAŞ H. C.

JOURNAL OF CLINICAL APHERESIS, cilt.37, sa.6, ss.600-605, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/jca.21999
  • Dergi Adı: JOURNAL OF CLINICAL APHERESIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.600-605
  • Anahtar Kelimeler: adverse drug reactions, drug hypersensitivity syndrome, plasma exchange, SYSTEMIC SYMPTOMS DRESS, DRUG REACTION, HYPERSENSITIVITY SYNDROME, EOSINOPHILIA
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome in children is a rare adverse drug reaction with skin rash, fever, hematologic abnormalities, and multiorgan involvement. The diagnosis is difficult because of its various clinical presentations, nonetheless is extremely important due to the mortality rate. We describe a 14-year-old boy who developed hypersensitivity to either teicoplanin or meropenem therapy. After failing to improve with corticosteroids, he was successfully treated with therapeutic plasma exchange (TPE). TPE should be considered in the treatment with corticosteroid-resistant DRESS syndrome.