Familial Lafora body disease of late onset: Report of four cases in one family and a review of the literature

Footitt D. R., Quinn N., Kocen R. S., ÖZ A. B., Scaravilli F.

Journal of Neurology, vol.244, no.1, pp.40-44, 1996 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 244 Issue: 1
  • Publication Date: 1996
  • Doi Number: 10.1007/s004150050048
  • Journal Name: Journal of Neurology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.40-44
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Lafora body disease is one cause of progressive myoclonus epilepsy. It typically presents in the second decade with generalized seizures, myoclonus and then intellectual de dine. Death is usual within 10 years. Diagnosis may be made by biopsy of skin, muscle, liver or brain. We present four siblings who were normal until their mid-twenties, but then developed intellectual decline, followed by myoclonus. Although a rare form of Lafora body disease has been described that follows a more benign course, may be of later onset, and whose pathology is subtly different, this family is so far unique in terms of the late presentation of otherwise typical Lafora body disease.