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JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.34, sa.8, ss.690-692, 2014 (SCI-Expanded, Scopus)
The ability of HbA(1c) was evaluated in the diagnosis of gestational diabetes mellitus (GDM) and for the implications of its use in clinical practice. A total of 339 pregnant women with an estimated gestational age of 24-28 weeks were evaluated for GDM using an oral glucose tolerance test (OGTT) based on International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria. A ROC curve was drawn to determine the sensitivity and specificity of HbA(1c) in detecting GDM. An HbA(1c) cut-off value of >= 5.2% had sensitivity of 64.15% and specificity of 67.48% in diagnosing GDM, and a positive predictive value of 26.77%. Using two cut-offs in the 'rule-in and rule-out' algorithm, 94.4% of the GDM cases would have been detected but 33% (43 of the 130) women would had been misclassified. HbA(1c) is not suitable to use alone for the diagnosis of GDM and is not useful in decreasing the need for OGT testing.