Lipid peroxidation and antioxidant status in maternal and cord blood
GYNECOLOGIC AND OBSTETRIC INVESTIGATION, cilt.51, sa.3, ss.145-149, 2001 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 3
- Basım Tarihi: 2001
- Doi Numarası: 10.1159/000052913
- Dergi Adı: GYNECOLOGIC AND OBSTETRIC INVESTIGATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.145-149
- Anahtar Kelimeler: cord blood, lipid peroxidation, oxidative stress, pregnancy, GLUTATHIONE-PEROXIDASE, FETAL HYPOXIA, SELENIUM, CATECHOLAMINES, PLASMA
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
The present study was undertaken to determine the change of blood lipid peroxide and antioxidant status in healthy nonpregnant women (n = 20), pregnant women in the third trimester (n = 20), pregnant women during delivery (n = 26) and fetal cord blood. Plasma and erythrocyte malondialdehyde (MDA) levels were found to be significantly higher and erythrocyte glutathione (GSH) levels were significantly lower in pregnant women in the third trimester th a n in nonpregnant women (p < 0.02, p < 0.03 and p < 0.001, respectively). The highest plasma and erythrocyte MDA levels and the fewest GSH levels were obtained from the pregnant women during delivery (6.99 +/- 2.35 nmol/ml, 283.20 +/- 43.81 nmol/g Hb, 6.73 +/- 2.34 mu mol/g Hb, respectively). Erythrocyte glutathione peroxidase (GSH-P) and glutathione reductase (GSH-R) activities were not different between the groups. Maternal plasma and erythrocyte MDA levels were significantly correlated with cord blood plasma and erythrocyte MDA levels (r = 0.63, p < 0.001, and r = 0.41, p < 0.001, respectively). There was a significant positive correlation in GSH-R and in GSH-P activities between maternal and cord blood erythrocytes (r = 0.81, p < 0.001, and r = 0.79, p < 0.001, respectively). A significant correlation was found between maternal erythrocyte GSH-P and both cord blood erythrocyte GSH-R activities (r = 0.74, p