Genetic variants of vitamin D metabolism-related <i>DHCR7/NADSYN1</i> locus and <i>CYP2R1</i> gene are associated with clinical features of Parkinson's disease.
The International journal of neuroscience, cilt.132, sa.5, ss.439-449, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 132 Sayı: 5
- Basım Tarihi: 2022
- Doi Numarası: 10.1080/00207454.2020.1820502
- Dergi Adı: The International journal of neuroscience
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE, Psycinfo
- Sayfa Sayıları: ss.439-449
- Anahtar Kelimeler: Parkinson's disease, vitamin D, DHCR7, NADSYN1, single nucleotide polymorphism, D-RECEPTOR GENE, ALZHEIMERS-DISEASE, D INSUFFICIENCY, D DEFICIENCY, POLYMORPHISMS, RISK, BONE, PREVALENCE
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Purpose/aim of the study: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Vitamin D deficiency is suggested to be related to PD. A genome-wide association study indicated that genes involved in vitamin D metabolism affect vitamin D levels. Among these genes, single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP/GC) genes have also been demonstrated to be associated with PD risk. Our aim was to investigate the relevance of SNPs within the 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) locus and vitamin D 25-hydroxylase (CYP2R1) gene, which encode important enzymes that play a role in the vitamin D synthesis pathway, with PD and its clinical features.