Genetic variants of vitamin D metabolism-related <i>DHCR7/NADSYN1</i> locus and <i>CYP2R1</i> gene are associated with clinical features of Parkinson's disease.

Alaylioglu M., Dursun E., Genc G., Sengul B., BİLGİÇ B., Gunduz A., ...Daha Fazla

The International journal of neuroscience, cilt.132, sa.5, ss.439-449, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 132 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/00207454.2020.1820502
  • Dergi Adı: The International journal of neuroscience
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.439-449
  • Anahtar Kelimeler: Parkinson's disease, vitamin D, DHCR7, NADSYN1, single nucleotide polymorphism, D-RECEPTOR GENE, ALZHEIMERS-DISEASE, D INSUFFICIENCY, D DEFICIENCY, POLYMORPHISMS, RISK, BONE, PREVALENCE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Purpose/aim of the study: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Vitamin D deficiency is suggested to be related to PD. A genome-wide association study indicated that genes involved in vitamin D metabolism affect vitamin D levels. Among these genes, single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP/GC) genes have also been demonstrated to be associated with PD risk. Our aim was to investigate the relevance of SNPs within the 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) locus and vitamin D 25-hydroxylase (CYP2R1) gene, which encode important enzymes that play a role in the vitamin D synthesis pathway, with PD and its clinical features.