The effects of systemic and intratumoral interleukin-12 treatment in C6 rat glioma model

Tanriover N., Ulu M. O., Sanus G. Z., Bilir A., Canbeyli R., Oz B., ...Daha Fazla

NEUROLOGICAL RESEARCH, cilt.30, sa.5, ss.511-517, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1179/174313208x289516
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.511-517
  • Anahtar Kelimeler: C6 glioma model, cytokine, glioma, immunotherapy, interleukin-12, treatment, COLONY-STIMULATING FACTOR, BRAIN-TUMORS, IN-VIVO, DENDRITIC CELLS, ANTITUMOR-ACTIVITY, RECOMBINANT IL-12, IMMUNOTHERAPY, LYMPHOCYTES, SURVIVAL, GAMMA
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective: Cytokine based immunotherapy has long been an exciting field for many investigators aiming to provide an effective alternative treatment modality for glioma management. Among these cytokines, interleukin-12 (IL-12) plays a crucial role in mediating inflammatory and antitumoral activity on the host defence. We have investigated the therapeutic role of systemic and local delivery of IL-12 in C6 rat glioma model and compared these two modalities.