Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer

Zheng, Jian; Hernandez, Jonathan; Doussot, Alexandre; Bojmar, Linda; Zambirinis, Constantinos; Costa-Silva, Bruno; van Beek, Elke; Mark, Milica; Molina, Henrik; Askan, GÖKÇE; Basturk, Olca; Gonen, Mithat; Kingham, T.; Allen, Peter; D'Angelica, Michael; DeMatteo, Ronald; Lyden, David; Jarnagin, William

doi:10.1016/j.hpb.2017.12.010

Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer

Zheng J., Hernandez J. M., Doussot A., Bojmar L., Zambirinis C. P., Costa-Silva B., ...Daha Fazla

HPB, cilt.20, sa.7, ss.597-604, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 7
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.hpb.2017.12.010
Dergi Adı: HPB
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.597-604
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background: Exosomes are nanovesicles that have been shown to mediate carcinogenesis in pancreatic ductal adenocarcinoma (PDAC). Given the direct communication of pancreatic duct fluid with the tumor and its relative accessibility, we aimed to determine the feasibility of isolating and characterizing exosomes from pancreatic duct fluid.