Fatal gastrointestinal bleeding and perforated duodenal ulcer: a rare complication of deferasirox in a patient with liver cirrhosis
BIOMEDICAL RESEARCH-INDIA, cilt.28, sa.12, ss.5620-5622, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 12
- Basım Tarihi: 2017
- Dergi Adı: BIOMEDICAL RESEARCH-INDIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
- Sayfa Sayıları: ss.5620-5622
- Anahtar Kelimeler: Gastrointestinal bleeding, Duodenal ulcer, Deferasirox, Liver cirrhosis, PORTAL-HYPERTENSION, IRON OVERLOAD, PHASE, ACID, RATS
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
We report here a case of deferoxamine (DFX) related gastrointestinal bleeding and duodenal perforation in a cirrhotic patient after the use of deferasirox for secondary hemochromatosis. Duodenal ulcer bleeding and perforation is noted as a rare adverse event in the scientific product information of deferasirox, in our current knowledge, this is the first case-report on this adverse drug reaction at adult patients. Clinicians must be aware that deferasirox use in a cirrhotic patient may have a potential risk of complicated gastrointestinal ulceration. It is recommended that patients undergoing treatment with deferasirox especially with liver cirrhosis are monitored regularly for adverse events.