The role of Mediterranean fever gene variants in patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome

Yildiz M., Adrovic A., Ulkersoy I., Gucuyener N., Koker O., Sahin S., ...More

EUROPEAN JOURNAL OF PEDIATRICS, vol.180, no.4, pp.1051-1058, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 180 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1007/s00431-020-03840-z
  • Journal Name: EUROPEAN JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.1051-1058
  • Keywords: Familial Mediterranean fever, MEFV, Periodic fever, Pyrin, PFAPA, APHTOUS STOMATITIS, PFAPA SYNDROME, COLCHICINE
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

This study was conducted to investigate the relationship between clinic features and Mediterranean fever gene (MEFV) variants in patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome. In total, 167 patients with PFAPA syndrome were included in the study. Female:male ratio of the patients was 0.75 (72 females, 95 males). In total 59.9% of patients with PFAPA had at least oneMEFVvariant and the most common heterozygous variants were M694V in 29.3% of the patients (40/167), E148Q in 8.3% (14/167), and V726A in 7.1% (12/167). The median age at the disease onset was significantly higher and the median duration of the episodes was significantly lower in patient with variants in exon 10 comparing to the others (bothp = 0.01). Similarly, the median age at the disease onset was significantly higher (p = 0.01) and the median duration of the episodes was significantly lower (p = 0.04) in patient withMEFVvariants than in the remaining patients. There were no significant differences according to the genotypes of the patients in terms of both treatment response and the frequency of clinical findings.