Akademik Veri Yönetim Sistemi
Phoenix Medical Journal, cilt.4, sa.1, ss.5-12, 2022 (Hakemli Dergi)
Objective: Early prognosis of sepsis, which affects millions of people all over the world every year and, can have
a mortality of more than 25%, is very important especially for emergency rooms where patients spend their most
critical golden hours. Lactate and lactate clearance are also potential marker candidates that can be used to
predict mortality, which has now started to take place in sepsis guidelines. The aim of this study is to investigate
the power of lactate and lactate clearance to predict mortality in sepsis.
Material and Method: All patients over the age of 18 with a diagnosis of severe sepsis and septic shock who
presented to the emergency department during a one-year period were included in this prospective observational
cohort study. The lactate clearance was calculated by taking the blood gase samples of the patients at the time
of admission and six hours later, and evaluated in terms of predicting mortality along with other parameters.
Results: The decrease in lactate values at the sixth hour of 90 patients included in the study was found to be
statistically significant (p=0.001). A positive and significant correlation was found between the lactate values of
the patients at admission and mortality (p=0.046). A negative significant correlation was found between lactate
clearance of the patients and mortality (p=0.001).
Conclusion: In patients with sepsis, lactate level is important in determining prognosis. Regardless of arrival
lactate level, the rise of lactate reduction rate at the sixth hour indicates a good prognosis. In addition, it was
determined that the sixth hour lactate level also had an effect on predicting mortality. When all these results
are taken into consideration, it can be said that the lactate level and lactate clearance are useful predictors of
prognosis in sepsis patients admitted to the emergency department. However, they are not sufficient on their own
to determine the prognosis and should be used together with other markers and clinical evaluation