Akademik Veri Yönetim Sistemi
Journal of the Turkish Chemical Society, Section A: Chemistry, cilt.6, sa.2, ss.119-132, 2019 (Scopus, TRDizin)
© 2019, Turkish Chemical Society. All rights reserved.Nanotechnology provides promising possibilities for several biomedical and pharmaceutical applications in the medical industry. Nanostructures play a major role in the recent strategies of technology suitable for novel drug applications. In this work, clindamycin phosphate (CliP) (topical anti-inflammatory drug), xanthan gum (XaG) (biopolymer) and ZnO (zinc oxide) (nanoparticle) nanostructures were synthesized using the sonochemical technique at room temperature. The characterization of the clindamycin phosphate-xanthan gum/ZnO (CliP-XaG/ZnO) nanostructure has been carried out by Fourier transform infrared (FTIR) and X-ray diffraction (XRD). The spectroscopic experiments elucidated the in vitro mechanism of drug delivery system at different pH media (1.2 and 7.4). In this study, the concentration of the drug in the solution was analyzed by UV-Vis spectrophotometric method and detailed error analysis were performed. The Higuchi gave the best correlation with the experimental data. The swelling behavior of the nanostructure was studied. The percentage of the swelling ratio of XaG/ZnO exerted a more significant effect than XaG at pH 1.2 and pH 7.4. The results show that the capacity of XaG/ZnO can be preferred as a novel topical anti-inflammatory drug carrier.