Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls

TSUBOI Y., Ahlskog J., Apaydin H., PARISI J., DICKSON d.

NEUROLOGY, cilt.57, sa.9, ss.1675-1678, 2001 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 9
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1212/wnl.57.9.1675
  • Dergi Adı: NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1675-1678
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective: To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). Background: LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. Methods: The authors evaluated the brains of 72 consecutive cases of pathologically confirmed PSP and 98 normal controls, ranging in age from 60 to 100 years, with immunohistochemistry for alpha -synuclein. Results: LB and Lewy neurites were found in 13 cases of PSP, with the most numerous LB and Lewy neurites in the basal forebrain and amygdala; most cases also had LB in the substantia nigra. The frequency of LB in the substantia nigra (12%) was comparable to the frequency of LB in controls (9%). Conclusions: In contrast to increased frequency of LB in AD, there is no apparent interaction between LB and the tau pathology in PSP.

Objective: To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP).
Background: LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases,
especially AD. Methods: The authors evaluated the brains of 72 consecutive cases of pathologically confirmed PSP and 98
normal controls, ranging in age from 60 to 100 years, with immunohistochemistry for -synuclein. Results: LB and Lewy
neurites were found in 13 cases of PSP, with the most numerous LB and Lewy neurites in the basal forebrain and
amygdala; most cases also had LB in the substantia nigra. The frequency of LB in the substantia nigra (12%) was
comparable to the frequency of LB in controls (9%). Conclusions: In contrast to increased frequency of LB in AD, there is
no apparent interaction between LB and the tau pathology in PSP.