Research Information System
in: Natural Products and Their Bioactives in Antidiabetic Drug Discovery, Kanti Bhooshan Pandey,Maitree Suttajit,Pinar Atukeren, Editor, John Wiley & Sons, West Sussex, UK , New Jersey, pp.308-336, 2023
Gestational
diabetes mellitus (GDM) is a type of diabetes that only pregnant women
experience. It is believed that it shares the same common patterns with other
diabetes types, particularly Type 2 (T2DM). Women with GDM have a risk of
developing T2DM after pregnancy and their infants have an increased risk of having
diabetes. The main reason for diabetes is insulin insufficiency, and diet,
environmental conditions and genetic background dictate the body to start or
stop insulin production. In our daily life, we take many macro and micronutrients
with our diet and these nutrients have direct effects on our cells and DNA.
These nutrients may act like transcription factors and control gene expression.
So far, considering the size of the scientific data produced all over the
world, the majority of the studies have focused on the sheer genetic background
of diseases, and only a fraction of them have investigated the effects of
nutrients on gene expression. Even a smaller part of them have investigated the
interaction between nutrients, genetic basis and GDM. This chapter aims to
explain this interaction briefly. However, the data is vast, and it is
necessary to dig deeper to understand the possible effects of nutrients on
genes in GDM.