Innovations in molecular methods for diagnosing sepsis Sepsis tanısı İçin moleküler yöntemlerdeki yenilikler

Özdemir Y. E., AYGÜN G.

Klimik Dergisi, vol.37, no.2, pp.76-82, 2024 (ESCI, Scopus, TRDizin) identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 2
  • Publication Date: 2024
  • Doi Number: 10.36519/kd.2024.4622
  • Journal Name: Klimik Dergisi
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.76-82
  • Keywords: Diagnosis, Molecular methods, Sepsis
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Sepsis is one of the leading causes of morbidity and mortality due to infections. Traditional blood culture methods have long been accepted as the gold standard reference method for diagnosing sepsis. However, conventional methods have many limitations, such as the long identification period of pathogenic microorganisms, low sensitivity, and the need for frequent repetition. Therefore, molecular methods, sequencing technologies, nanoparticles, microfluidic systems, biosensors, and artificial intelligence algorithms have been used to diagnose of sepsis. This review will discuss molecular techniques for rapidly identifying the causative microorganism, especially on whole blood samples, and commercial tests developed based on these molecular methods.