DLEC1 is not silenced solely by promoter methylation in head and neck squamous cell carcinoma

Seven D., Yavuz E., Kilic E., Baltaci E., Karaman E., Ulutin T., ...Daha Fazla

GENE, cilt.563, sa.1, ss.83-86, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 563 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.gene.2015.03.004
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.83-86
  • Anahtar Kelimeler: DLEC1, Expression, HNSCC, Methylation, Tumor suppressor, TUMOR-SUPPRESSOR GENE, FREQUENT EPIGENETIC INACTIVATION, CANCER EPIDEMIOLOGY CONSORTIUM, LUNG-CANCER, SHORT ARM, NASOPHARYNGEAL CARCINOMA, INTERNATIONAL HEAD, CHROMOSOME 3P21.3, CPG METHYLATION, DNA METHYLATION
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Different types of genetic and epigenetic changes are associated with HNSCC. The molecular mechanisms of HNSCC carcinogenesis are still undergoing intensive investigation. The Deleted in lung and esophageal cancer 1 (DLEC1) gene is frequently silenced by methylation in various kinds of cancer. However, there is no data in the literature investigating the DLEC1 gene in the HNSCC.