Production of the novel fibrous structure of poly(epsilon-caprolactone)/tri-calcium phosphate/hexagonal boron nitride composites for bone tissue engineering

Ozbek B., Erdogan B., Ekren N., Oktar F. N., Akyol S., Ben-Nissan B., ...More

JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, vol.54, pp.251-260, 2018 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2018
  • Doi Number: 10.1007/s41779-017-0149-0
  • Journal Name: JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.251-260
  • Keywords: Biopolymers, Biofibers, Biomaterials, Poly(epsilon-caprolactone), Composites, POLYCAPROLACTONE, SCAFFOLDS, FABRICATION
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Nanofibrous composites of the poly(epsilon-caprolactone) (PCL), tricalcium phosphate (TCP), and hexagonal boron nitride (h-BN) with different compositions were manufactured by using an economical and non-complicated method called electrospinning. Produced fibrous structures showed no bead formation and had a clean surface. Characterization of the composites showed that particles were successfully mixed with polymer phase. High cell activity of SaOS-2 cells on the composites was observed with SEM images. In addition, fibrous scaffolds are biocompatible with human bone tissue and are highly degradable.