Production of the novel fibrous structure of poly(epsilon-caprolactone)/tri-calcium phosphate/hexagonal boron nitride composites for bone tissue engineering

Ozbek, Burak; Erdogan, Barkin; Ekren, Nazmi; Oktar, Faik; Akyol, SİBEL; Ben-Nissan, Besim; Türkoğlu Şaşmazel, Hilal; Kalkandelen, CEVRİYE; Mergen, Ayhan; Kuruca, Serap; Ozen, Gunes; Gündüz, Oğuzhan

doi:10.1007/s41779-017-0149-0

Production of the novel fibrous structure of poly(epsilon-caprolactone)/tri-calcium phosphate/hexagonal boron nitride composites for bone tissue engineering

Ozbek B., Erdogan B., Ekren N., Oktar F. N., Akyol S., Ben-Nissan B., ...Daha Fazla

JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, cilt.54, ss.251-260, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 54
Basım Tarihi: 2018
Doi Numarası: 10.1007/s41779-017-0149-0
Dergi Adı: JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.251-260
Anahtar Kelimeler: Biopolymers, Biofibers, Biomaterials, Poly(epsilon-caprolactone), Composites, POLYCAPROLACTONE, SCAFFOLDS, FABRICATION
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Nanofibrous composites of the poly(epsilon-caprolactone) (PCL), tricalcium phosphate (TCP), and hexagonal boron nitride (h-BN) with different compositions were manufactured by using an economical and non-complicated method called electrospinning. Produced fibrous structures showed no bead formation and had a clean surface. Characterization of the composites showed that particles were successfully mixed with polymer phase. High cell activity of SaOS-2 cells on the composites was observed with SEM images. In addition, fibrous scaffolds are biocompatible with human bone tissue and are highly degradable.