The investigation of antimicrobial peptides expression and its related interaction with methotrexate treatment in patients with psoriasis vulgaris

Ozlu E., KARADAĞ A. S., ÖZKANLI S. Ş., Oguztuzun S., Akbulak O., Uzuncakmak T. K., ...Daha Fazla

CUTANEOUS AND OCULAR TOXICOLOGY, cilt.36, sa.4, ss.321-326, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/15569527.2016.1277430
  • Dergi Adı: CUTANEOUS AND OCULAR TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.321-326
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background: Psoriasis is a chronic, inflammatory and immune-mediated disease. Recently, the role of antimicrobial peptides (AMPs) such as human beta defensins (hBDs) in the pathogenesis of psoriasis has been investigated. We aimed to evaluate the expression profiles of hBD-1 and hBD-2 in psoriatic skin before and after methotrexate (MTX) therapy and to compare healthy controls.