The investigation of antimicrobial peptides expression and its related interaction with methotrexate treatment in patients with psoriasis vulgaris

Ozlu E., KARADAĞ A. S., ÖZKANLI S. Ş., Oguztuzun S., Akbulak O., Uzuncakmak T. K., ...More

CUTANEOUS AND OCULAR TOXICOLOGY, vol.36, no.4, pp.321-326, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1080/15569527.2016.1277430
  • Journal Name: CUTANEOUS AND OCULAR TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.321-326
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Background: Psoriasis is a chronic, inflammatory and immune-mediated disease. Recently, the role of antimicrobial peptides (AMPs) such as human beta defensins (hBDs) in the pathogenesis of psoriasis has been investigated. We aimed to evaluate the expression profiles of hBD-1 and hBD-2 in psoriatic skin before and after methotrexate (MTX) therapy and to compare healthy controls.