Association between MTHFR C677T polymorphism and folate, vitamin B12, homocysteine, and DNA fragmentation in patients with ovarian cancer

Ozkilic A. C., Cetin A., Bayoglu B., Balci H., Cengiz M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.41, sa.6, ss.459-465, 2016 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1515/tjb-2016-0151
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.459-465
  • Anahtar Kelimeler: Ovarian cancer, MTHFR gene, C677T polymorphism, Homocysteine, Folic acid, Vitamin B12, Comet assay, METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM, VASCULAR-DISEASE, GENETIC RISK, COMET ASSAY, MUTATION, BREAST, STATISTICS, DEFICIENCY, LEADS
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme that regulates the metabolism of methionine and folate. MTHFR C677T polymorphism was reported to be associated with breast and ovarian cancer. The aim of this study was to evaluate the association between the MTHFR C677T (rs1801133) polymorphism and homocysteine, vitamin B-12, and folate levels, and DNA fragmentation in patients with ovarian cancer and healthy controls.