Efficacy of interferon alpha-2b and lamivudine combination treatment in comparison to interferon alpha-2b alone in chronic delta hepatitis: A randomized trial
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.21, sa.4, ss.657-663, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 4
- Basım Tarihi: 2006
- Doi Numarası: 10.1111/j.1440-1746.2006.04082.x
- Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.657-663
- Anahtar Kelimeler: interferon, lamivudine, delta hepatitis, D VIRUS-INFECTION, 12-MONTH COURSE, THERAPY, ALPHA
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Background and Aim: Delta hepatitis is characterized by rapidly progressive liver disease with adverse prognosis in most patients. Patients benefit from high doses and prolonged courses of interferon (IFN) therapy; however, lamivudine as a single agent has been disappointing. Data relating to the efficacy of IFN and lamivudine in combination is limited. The aim of this study was to test the efficacy of IFN-alpha 2b and lamivudine combination treatment in comparison to IFN-alpha 2b alone in patients with chronic delta hepatitis.