Therapeutic vaccination in chronic hepatitis B

Senturk H., Tabak F., Akdogan M., Erdem L., Mert A., Ozaras R., ...Daha Fazla

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.17, sa.1, ss.72-76, 2002 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1046/j.1440-1746.2002.02652.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.72-76
  • Anahtar Kelimeler: chronic hepatitis B, interferon-alpha, treatment, vaccine, E-ANTIGEN, SURFACE-ANTIGEN, TRANSGENIC MICE, VIRUS, LAMIVUDINE, INTERFERON, ALPHA, RESPONSIVENESS, DETERMINANT, MECHANISM
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Aims: The aim was to test the efficacy of a pre-S2-containing vaccine (Genhevac-B) in chronic hepatitis B (CHB). Twenty-five naive patients (22 male, three female; median age 35; range: 6-69 years) with CHB were recruited. The inclusion criteria were: hepatitis B e antigen (HBeAg) positive or HBV-DNA detectable with liquid hybridization; alanine aminotransferase (ALT) is at least 1.5-fold the upper normal limit and histological evidence of chronic hepatitis.