Simultaneous Electrochemical Determination of alpha-Tocopherol and Retinol in Micellar Media by a Poly(2,2 '-(1,4 Phenylenedivinylene)-bis-8-Hydroxyquinaldine)-Multiwalled Carbon Nanotube Modified Electrode

Filik H., Avan A. A., Aydar S.

ANALYTICAL LETTERS, vol.49, no.8, pp.1240-1257, 2016 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 8
  • Publication Date: 2016
  • Doi Number: 10.1080/00032719.2015.1094665
  • Journal Name: ANALYTICAL LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1240-1257
  • Keywords: Carbon nanotubes, fat-soluble vitamin, glassy carbon electrode, pharmaceutical, retinol, alpha-tocopherol, voltammetry, PERFORMANCE LIQUID-CHROMATOGRAPHY, FAT-SOLUBLE-VITAMINS, TANDEM MASS-SPECTROMETRY, SOLID-PHASE EXTRACTION, DIODE-ARRAY DETECTION, VOLTAMMETRIC BEHAVIOR, SURFACTANT MEDIA, VEGETABLE-OILS, BETA-CAROTENE, BREAST-MILK
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

A novel method was developed for the simultaneous electrochemical determination of alpha-tocopherol (viatmin E) and retinol (vitamin A) using a poly(2,2'-(1,4-phenylenedivinylene)-bis-8-hydroxyquinaldine)/multiwalled carbon nanotube modified glassy carbon electrode. The simple and rapid voltammetric approach was evaluated for real samples using Triton X-100 to solubilize the analytes in the absence of organic solvent. The calibration graph for alpha-tocopherol was linear from 8 to 100 mu M with a limit of detection of 0.1 mu M in the presence of 80 mu M retinol. The response was also linear with retinol concentration from 5 to 200 mu M with a detection limit of 0.8 mu M in the presence of 40 mu M alpha-tocopherol. The developed method was employed for the determination of the vitamins in pharmaceutical products.