Bayrak B. B., Babayev M., Magaji U., Saçan Ö., Yanardağ R.
European Journal of Biology, cilt.85, sa.2, ss.94-101, 2026 (ESCI, TRDizin)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
85
Sayı:
2
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Basım Tarihi:
2026
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Doi Numarası:
10.26650/eurjbiol.2026.1027253
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Dergi Adı:
European Journal of Biology
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Derginin Tarandığı İndeksler:
Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.94-101
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İstanbul Üniversitesi-Cerrahpaşa Adresli:
Evet
Özet
Objective: Valproic acid (VPA) and its salts are psychotropic medications that are widely used to treat neurological diseases, such as epilepsy, migraine, and neuropathic pain, as well as psychiatric disorders, such as schizophrenia, addiction, and bipolar mood disorder. Moringa extract contains antioxidant, antimicrobial, antidiabetic, cardioprotective, and anti-inflammatory compounds that may support human health.Materials and Methods: This study aimed to investigate the possible protective effects of Moringa hydroalcoholic extract (MOL) against sodium valproate (SVP)-induced damage to brain glycoproteins and hydroxyproline. Female rats (Sprague Dawley) were randomly assigned to the following four groups: control, MOL, SVP, and SVP + MOL. SVP and MOL were administered at doses of 500 and 300 mg/kg body weight, respectively, for 15 days. Rats were sacrificed on day 16. The collection and subsequent homogenisation of brain tissue was conducted using a physiological saline solution at a ratio of 10% (weight/volume). The levels of sialic acid, hexose, hexosamine, fucose, and hydroxyproline were determined in the brain tissue.Results: Statistical analysis revealed a significant increase in glycoprotein and hydroxyproline levels in the brain tissue of rats treated with SVP. The administration of a hydroalcoholic extract of MOL to rats treated with SVP resulted in the recovery of these alterations, thus preventing or reducing brain damage.Conclusion: The hydroalcoholic extract of Moringa exerts an attenuating effect on brain damage associated with increased glycoprotein and hydroxyproline levels caused by SVP.