Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders

Cengiz M., Cezayirli E., Bayoğlu B., Aslıyüksek H., Kocabaşoğlu N.

INDIAN JOURNAL OF PSYCHIATRY, cilt.61, sa.3, ss.253-257, 2019 (SCI-Expanded, SSCI, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4103/psychiatry.indianjpsychiatry_194_18
  • Dergi Adı: INDIAN JOURNAL OF PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.253-257
  • Anahtar Kelimeler: Brain-derived neurotrophic factor, catechol-O-methyl transferase, paraphilia, polymorphism, sexual abuse, VAL(158)MET POLYMORPHISM, ABUSE, BDNF, COMT, DOPAMINE, ASSOCIATION, RECEPTOR, MEN, TRANSMISSION, DEPRESSION
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background: Child sexual abuse (CSA) is an important problem worldwide. The reason of sex abuse is considered as multifactorial. Genetic contribution reported by recent studies is a significant evidence for this pathologic behavior. Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. COMT polymorphism causes functional changes in COMT enzyme activity. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor usually synthesized from central nervous system neurons. With the effect of BDNF, dopamine and serotonin play important roles on neurogenesis, survival, and synaptic plasticity.