Significant Heterogeneity in Pooled Patient Acceptable Symptom State Threshold for Shoulder Pain: A Systematic Review and Meta-analysis


Ozkutlu O., EREKDAĞ A., Tongar S. S., Namli Seker A., Georgopoulos V., ÇELİK D.

Arthroscopy - Journal of Arthroscopic and Related Surgery, cilt.41, sa.11, ss.4752, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

Özet

Purpose: To identify studies reporting patient acceptable symptom state (PASS) thresholds in diverse shoulder pain populations and to investigate whether patient-reported outcome measurements measuring shoulder pain severity provide similar estimates of the PASS across groups of people experiencing shoulder pain. Methods: Web of Science, Scopus, CENTRAL, and OVID (MEDLINE) databases were searched for studies on PASS related to shoulder pain using terms for PASS, shoulder pathologies, and pain-related patient-reported outcome measurements. Risk of bias (RoB) was categorized using a modified the Quality in Prognosis Studies Tool. The meta-analysis applied random effects models, with heterogeneity assessed via I2 and Cochran's Q-test. Subgroup analysis was performed, with bias evaluated using funnel plots and the Egger test. Results: Twenty-one studies were included, involving 8.992 participants with an average age of 50.55 years. The PASS thresholds for shoulder pain varied across the interventions and follow-up periods. The pooled PASS estimate was 20.18 (95% confidence interval 16.63-23.73, prediction interval 2.98 to 37.38), with significant heterogeneity (I2 = 97%). Surgical interventions had lower PASS thresholds than nonsurgical approaches. Studies with longer follow-up duration and moderate RoB had lower PASS thresholds. A significant publication bias was identified. Conclusions: This systematic review and meta-analysis established a pooled PASS threshold for shoulder pain, highlighting substantial heterogeneity and significant differences in PASS thresholds across RoB levels, follow-up durations, and types of intervention. Level of Evidence: Level IV, systematic review and meta-analysis of Level II-IV studies.