Akademik Veri Yönetim Sistemi
Pakistan journal of pharmaceutical sciences, cilt.37, sa.6, ss.1331-1341, 2024 (SCI-Expanded)
Antimicrobial peptides (AMPs) may mitigate the danger of increasing antimicrobial resistance. We aimed to determine the activities of catestatin, temporin A, nisin and cecropin A against Bacteroides fragilis ATCC 25285,
Prevotella melaninogenica ATCC 25845, Cutibacterium acnes ATCC 6919, Peptostreptococcus anaerobius ATCC27337 and Peptostreptococcus stomatis DSM 17678. strains. The susceptibility of all anaerobic bacteria was determined
by Kirby-Bauer disc diffusion method, agar dilution and broth microdilution method, recommended by CLSI. By broth microdilution the MIC of temporin A for P. anaerobius was 500μg/mL, and MBC >500μg/mL. The MIC of nisin for
P.melaninogenica was 200μg/mL, with a MBC of 400μg/mL, for C. acnes, P. anaerobius, and P. stomatis, MIC were 40mg/mL. The MIC of cecropin A for B. fragilis was 50μg/mL, MBC was 500μg/mL. For C. acnes, the MIC was
4μg/mL, MBC was 8μg/mL. The MIC for P. melaninogenica, P. anaerobius and P. stomatis were 8μg/mL, with corresponding MBC values of 16, 32 and 50μg/mL, respectively. Conversely, catestatin proved ineffective against all
strains. In conclusion, our study, demonstrated that cecropin A and nisin showed promising results against anaerobic standard strains. We believe thatfurther research conducted to explore those AMPs could hold promise as a treatment
option for anaerobic bacterial infections.