The effect of CyA and verapamil on the rats having skin graft DERI GREFTI YAPILMIS SICANLARDA SIKLOSPORIN A VE VERAPAMILIN IN VIVO VE IN VITRO ETKILERI

TÜZÜN B., Kaygusuz A., Cetinkale O., Gurel N., Alkan S., ORAL A., ...Daha Fazla

Turkderm Deri Hastaliklari ve Frengi Arsivi, cilt.28, sa.4, ss.213-216, 1994 (ESCI, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 1994
  • Dergi Adı: Turkderm Deri Hastaliklari ve Frengi Arsivi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.213-216
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background and Design. - Verapamil, a calcium channel blocker and Cyclosporin A (CyA) inhibit blastic transformation to lectins. These drugs have synergistic effects in vitro. This study have designed to compare in vivo and in vitro results based on the effect of skin graft rejection on rats receiving CyA and verapamil. Methods. - Complete thickness skin defects on the back of 26 Wistar-Albino white rats, grafted by the skin of gray wild rats. CyA + verapamil; CyA; and sesame oil were administered to three groups of rats for 21 days. After grafting, at 18th hour and on 22th day the heart blood were collected and assayed blood culture with and without phytohaemagglutinin (PHA) and the ratio of CD4/CD8 by flow cytometry. Conclusion. - CyA and verapamil did not suppress lymphoblastic transformation to lectins in vitro and in vivo and did not change the ratio of CD4/CD8 (p > 0.05 and p > 0.05 respectively).