Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia

AK H., Ay B., Tanriverdi T., Sanus G. Z., IS M., Sar M., ...Daha Fazla

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, cilt.16, sa.6, ss.493-503, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.seizure.2007.03.011
  • Dergi Adı: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.493-503
  • Anahtar Kelimeler: epilepsy, multidrug resistance, proteins, MDR1, MRP1, MDR1 GENE-EXPRESSION, BLOOD-BRAIN-BARRIER, P-GLYCOPROTEIN, DRUG-RESISTANCE, TRANSPORTERS, EPILEPSY, SEIZURES
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Recent arouse of interest indicated that drug resistant proteins are markedly over-expressed in the epileptogenic tissue and they may be responsible for the one-third of the epileptic patients who were refractory to anti-epileptic drugs (AEDs). Since several AEDs may act as substrates for these drug resistant proteins, the enhanced function of such proteins may increase drug extrusion, resulting in inadequate response to drug therapy in patients with epilepsy.