The role of unfolded protein response in the pathogenesis of endometriosis: contribution of peritoneal fluid.

Ekiz-Yilmaz T., Isildar B., Gezer A., Kankaya D., Cansiz-Ersoz C., Kayisli U., ...More

Reproductive biomedicine online, vol.42, no.0, pp.1-15, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 0
  • Publication Date: 2021
  • Doi Number: 10.1016/j.rbmo.2020.09.012
  • Journal Name: Reproductive biomedicine online
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.1-15
  • Keywords: Endometriosis, Endoplasmic reticulum stress, Human endometrial stromal cells, Peritoneal fluid, p-IRE1, ENDOPLASMIC-RETICULUM STRESS, MESENCHYMAL TRANSITION, EUTOPIC ENDOMETRIUM, STROMAL CELLS, APOPTOSIS, EXPRESSION, CYTOKINES, PROLIFERATION, BIOMARKERS, WOMEN
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Research question: Endoplasmic reticulum stress (ERS) is caused by the accumulation of the misfolded or unfolded proteins in the endoplasmic reticulum and induces the unfolded protein response (UPR). Peritoneal fluid is important in the pathogenesis of endometriosis. In this study, the role of UPR associated with ERS in endometriosis, and peritoneal fluid, were investigated.