Synthesis of novel 1,4-naphthoquinone derivatives: antibacterial and antifungal agents

Ibis, Cemil; Tuyun, Amac; Bahar, HAKAN; Ayla, SİBEL; Stasevych, Maryna; Musyanovych, Rostyslav; Komarovska-Porokhnyavets, Olena; Novikov, Volodymyr

doi:10.1007/s00044-012-0300-y

Synthesis of novel 1,4-naphthoquinone derivatives: antibacterial and antifungal agents

Ibis C., Tuyun A. F., Bahar H., Ayla S., Stasevych M. V., Musyanovych R. Y., ...Daha Fazla

MEDICINAL CHEMISTRY RESEARCH, cilt.22, sa.6, ss.2879-2888, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22 Sayı: 6
Basım Tarihi: 2013
Doi Numarası: 10.1007/s00044-012-0300-y
Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2879-2888
Anahtar Kelimeler: Thio and amino substituted, 1,4-naphthoquinones, Antibacterial and antifungal activity, BIOLOGICAL EVALUATION, SOLID-STATE, 5-ARYLAMINO-2-METHYL-4,7-DIOXOBENZOTHIAZOLES, INHIBITORS
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

A novel series of substituted 1,4-naphthoquinone derivatives was synthesized and evaluated for antibacterial and antifungal activity. The structures of the novel products were characterized by spectroscopic methods. Among the tested compounds, 3a and 9 are the most effective compounds against M. luteum as potent antibacterial and C. tenuis and A. niger as potent antifungal. These two compounds are promising as biologically active compounds.