Determination of necessary parameters to decide the second treatment for those who failed a single dose methotrexate therapy

Kiliç B. S., Tüten A., Öncül M., Açikgöz A. S.

MEDICAL JOURNAL OF BAKIRKOY, no.3, pp.107-110, 2014 (ESCI, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2014
  • Doi Number: 10.5350/btdmjb201410304
  • Journal Name: MEDICAL JOURNAL OF BAKIRKOY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.107-110
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Objective: To determine necessary parameters to decide the second treatment for those who failed a single dose methotrexate therapy. Material and methods: 32 ectopic pregnancy patients who fail a single dose methotrexate treatment between 2000 and 2010 have been divided into two groups for secondary treatment; surgical and medical treatments. Clinical and laboratory characteristics of the patient groups were compared. Results: 23 patients were treated surgically and medical treatment was repeated in 9 patients. There was no difference in terms of gestational age, baseline serum beta-hCG level and the size of ectopic pregnancy for both surgical and medical treatment of the patients. Surgery was performed in all patients who developed hemodynamic instability. Serum beta-hCG values were significantly higher in patients with hemodynamic instability than those who are hemodynamically stable (10374 +/- 14.554 vs. 4225 +/- 3429, p: 0.001). Conclusion: The most important parameter is hemodynamic instability to decide the second treatment for those failed a single dose methotrexate therapy.