Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine
POLYMERS, cilt.6, sa.1, ss.214-242, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.3390/polym6010214
- Dergi Adı: POLYMERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.214-242
- Anahtar Kelimeler: polymeric drug delivery systems, micelle, nano formulation, targeted cancer therapy, vinorelbine, amphiphilic block copolymer, star-shaped polymer, Y-shaped polymer, RING-OPENING POLYMERIZATION, ALDER CLICK REACTION, DRUG-DELIVERY, POLY(ETHYLENE GLYCOL), BREAST-CANCER, MICELLES, NANOPARTICLES, RELEASE, SOLUBILIZATION, NANOMEDICINE
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Two amphiphilic block copolymers using hydrophobic poly(e-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B)(4) type star polymer [(PCL-b-PEG)(4)] and the other one is a Y-shaped PEG-(PCL)(2). A star-shaped polymer (PCL-b-PEG)(4) was prepared by ring-opening polymerization (ROP) of epsilon-caprolactone continued by click reaction of (PCL-azide)(4) and PEG-alkyne. The synthesis of Y-shaped PEG-(PCL)(2) block copolymer was carried out via Diels-Alder click reaction of a furan protected maleimide end-functionalized PEG (PEG-MI) with an anthracene end-functionalized PCL following the ROP of epsilon-caprolactone. The characterization of micelles is carried out using both materials in aqueous media as drug delivery vehicles, which showed satisfying results and enhanced the cytotoxic effect of the anti-cancer drug vinorelbine (VLB). However, micelles consisted of Y-shaped unimers were found to be more convenient for delivery of hydrophobic drugs such as VLB because they formed in lower concentration, carrying a higher amount of drugs and owing a monomodal distribution. We concluded that the free tails of hydrophobic chains in Y-shaped block copolymer facilitate the assembly of amphiphilic material in water to form micelles.