Serum Vasostatin-1 Level is Increased in Women with Preeclampsia

Tuten N., TÜTEN A., Gok K., HAMZAOĞLU K., Bulut H., Malik E., ...Daha Fazla

ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE, cilt.226, sa.03, ss.178-185, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 226 Sayı: 03
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1055/a-1747-3738
  • Dergi Adı: ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.178-185
  • Anahtar Kelimeler: Angiogenesis, blood pressure, chromogranin A, peptide fragment, CHROMOGRANIN-A, VASOINHIBITORY ACTIVITY, ANGIOGENIC FACTORS, SOLUBLE ENDOGLIN, PATHOGENESIS, PEPTIDES, FRAGMENT, DYSFUNCTION, CORONARY, RISK
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Objective To evaluate the serum vasostatin-1 levels in preeclamptic and non-preeclamptic pregnant women. Materials and methods Thirty consecutive women with mild preeclampsia and sixty consecutive women with severe preeclampsia were compared with ninety gestational age-matched (+/- 1 week) non-preeclamptic pregnant women with an appropriate-for-gestational-age (AGA) fetus. Results Mean serum vasostatin-1 was significantly higher in women with preeclampsia than gestational age-matched controls. Mean serum vasostatin-1 was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group, and in the severe preeclampsia group compared to its gestational age-matched control group. There was no significant difference in mean serum vasostatin-1 levels between the mild and severe preeclampsia groups, and in severe early- and severe late-onset preeclampsia groups. Serum vasostatin-1 had positive correlations with systolic and diastolic blood pressure. Conclusion Serum vasostatin-1 was significantly higher in women with preeclampsia compared to those of the gestational age-matched controls. There was no significant difference in mean serum vasostatin-1 levels between the mild and severe preeclampsia groups and severe early- and severe late-onset preeclampsia groups.