Investigation of Thermodynamic and Morphological Properties of Crystalline 4-HPG (4-hydroxyphenylglycine) Using Raman, PXRD and DTA/TGA

Fatih Ergin M. F.

Journal of the Turkish Chemical Society, Section A: Chemistry, cilt.11, sa.2, ss.889-898, 2024 (Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.18596/jotcsa.1369980
  • Dergi Adı: Journal of the Turkish Chemical Society, Section A: Chemistry
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.889-898
  • Anahtar Kelimeler: 4-hydroxyphenylglycine, crystallization, impurity, pharmaceutical analysis, stability
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

This study focuses on the detailed physical characterization of 4-HPG, a significant impurity found in some of the most commonly prescribed β-lactam antibiotics worldwide. Various analytical techniques, including X-ray powder diffractometry, dynamic light scattering, scanning electron microscopy, Fourier-transform infrared, and Raman spectroscopy, were employed to characterize the properties of 4-HPG crystals. XRD analysis revealed the crystallinity and small crystallite sizes of 4-HPG particles, supported by DLS and SEM analyses. FT-IR and Raman spectroscopy results exhibited excellent agreement, providing insight into the structural characterization of 4-HPG. Thermal analysis revealed a two-stage degradation feature of 4-HPG. Overall, this study contributes to a better understanding of 4-HPG's structure and its impact on antibiotic stability.