Deficient prepulse inhibition of blink reflex in migraine and its relation to allodynia


Uygunoglu U. , Gunduz A. , Ertem H. D. , Uluduz D. , Saip S. , Goksan B., ...More

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, vol.47, no.1, pp.63-68, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1016/j.neucli.2016.09.002
  • Title of Journal : NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
  • Page Numbers: pp.63-68
  • Keywords: Allodynia, Blink reflex, Migraine, Prepulse inhibition, PEDUNCULOPONTINE TEGMENTAL NUCLEUS, STEM INTERNEURONAL CIRCUITS, BRAIN-STEM, TRIGEMINAL NOCICEPTION, CUTANEOUS ALLODYNIA, PRIMARY HEADACHES, STARTLE REACTION, EXCITABILITY, HABITUATION, SENSITIZATION

Abstract

Objective. - Prepulse inhibition (PPI) of the blink reflex (BR) is a reduction in BR excitability due to a conditioning stimulus, reflecting sensory gating by brainstem structures. We aimed to analyze PPI changes during a painful episode in chronic or episodic migraine and its relation to allodynia, since abnormal brainstem filtering has been hypothesized in migraine pathophysiology.