Deficient prepulse inhibition of blink reflex in migraine and its relation to allodynia

Uygunoglu, UĞUR; Gunduz, AYŞEGÜL; Ertem, Harika; Uluduz, Derya; Saip, SABAHATTİN; Goksan, Baki; Siva, AKSEL; Uzun, Nurten; Karaali-Savrun, FERAY; Kiziltan, Meral

doi:10.1016/j.neucli.2016.09.002

Deficient prepulse inhibition of blink reflex in migraine and its relation to allodynia

Uygunoglu U., Gunduz A., Ertem H. D., Uluduz D., Saip S., Goksan B., ...Daha Fazla

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, cilt.47, sa.1, ss.63-68, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 47 Sayı: 1
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.neucli.2016.09.002
Dergi Adı: NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.63-68
Anahtar Kelimeler: Allodynia, Blink reflex, Migraine, Prepulse inhibition, PEDUNCULOPONTINE TEGMENTAL NUCLEUS, STEM INTERNEURONAL CIRCUITS, BRAIN-STEM, TRIGEMINAL NOCICEPTION, CUTANEOUS ALLODYNIA, PRIMARY HEADACHES, STARTLE REACTION, EXCITABILITY, HABITUATION, SENSITIZATION
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective. - Prepulse inhibition (PPI) of the blink reflex (BR) is a reduction in BR excitability due to a conditioning stimulus, reflecting sensory gating by brainstem structures. We aimed to analyze PPI changes during a painful episode in chronic or episodic migraine and its relation to allodynia, since abnormal brainstem filtering has been hypothesized in migraine pathophysiology.