Akademik Veri Yönetim Sistemi
Academic Research And Reviews in Science and Mathematics, Berkan Balpetek,Assist Prof. Mine SULAK Ph.D, Editör, Duvar Publishing, İzmir, ss.35-54, 2021
Chalcones, generally composed of two aromatic rings
connected α, β-unsaturated carbonyl system which a threecarbon, are naturally found in vegetables, fruits, teas and other
plants and are involved in the biosynthesis of isoflavonoids and
flavonoids in plants (Rashid et al., 2019). They are very important
class because of medicinal and pharmacological properties like
anticancer (Modzelewska et al., 2006), antitumor (Jin et al.,
2013), anti-diabetics (Ugwu et al., 2015), anti-HIV (Rizvi et al.,
2012), antioxidants (Mazzone et al., 2015), antiulcer (Sashidhara
et al., 2015), antimalarial (Raj et al., 2015), cardiovascular
(Mahapatra and Bharti, 2016), anti-tubercular (Mujahid et al.,
2015), antibacterial (Mujahid et al., 2015), antifungal (Zheng
et al., 2015), antiviral (Zhou et al., 2018), anti-inflammatory
(Mahapatra et al., 2017), anticonvulsant (Sharma et al., 2013),
antidiuretic (Rizvi et al., 2012). Naturally derived chalcones are
usually yellow, orange and brown colored crystalline solids.
Coumarin composed of benzene and 2-pyron rings is a
bicyclic heterocyclic compound and is also a broad natural class.
Coumarin derivatives show a lot of pharmacological activities
(Sashidhara et al., 2013; Emami and Dadashpour, 2015),
such as anticarcinogenic (Basanagouda et al., 2014), antiviral
(Curini et al., 2003), anticholinesterase (Kurt et al., 2015), antiinflammatory (Fylaktakidou et al., 2004), antithrombotic (Peng
et al., 2013), antioxidant (Kostova et al., 2011), hepatoprotective
(Atmaca et al., 2011), , antimicrobial (Ostrov et al., 2007),
antituberculosis (Manvar et al., 2011), antihyperlipidemic (Yuce
et al., 2009) and monoamine oxidase-B inhibitors (Hammuda et
al., 2016) activities.