Sensitive Determination of 5-Fluorouracil with Anion Exchange Solid-Phase Extraction and a Ti3C2Tx MXene/VO2@MoO2 Electrochemical Sensor

AVAN A. A., Filik H.

Analytical Letters, cilt.59, sa.5, ss.800-824, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 5
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1080/00032719.2025.2507787
  • Dergi Adı: Analytical Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.800-824
  • Anahtar Kelimeler: 5-fluorouracil, Anion exchange solid-phase extraction, antineoplastic, differential pulse voltammetry (DPV), electrochemical sensor, MXene
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Solid-phase extraction with an anion exchange resin was used together with electrochemical detection on a glassy carbon electrode that was modified with Ti3C2TxMXene /VO2@MoO2 composites to measure 5-fluorouracil. The VO2@MoO2 composites were synthesized via a precipitation process combined with the hydrothermal method. The nanomaterials were characterized in terms of their structure, composition, and morphology. The key processing parameters affecting the solid-phase extraction and electrochemical determination were optimized. The linear response was from 0.01 to 35 μM, with a detection limit of 2.2 nM. The proposed method was applied to determine 5-fluorouracil in urine and water samples with satisfactory recoveries (90-92%).