De novo X/X translocation in a patient with secondary amenorrhea.

Tarkan, YELDA; Hacıhanefıoglu, S; Sılahtaroglu, An; Devıren, AYHAN; Topcuoglu, D; Cenanı, A

doi:10.1111/j.1601-5223.1995.00019.x

De novo X/X translocation in a patient with secondary amenorrhea.

Tarkan Y., Hacıhanefıoglu S., Sılahtaroglu A., Devıren A., Topcuoglu D., Cenanı A.

Hereditas, cilt.122, ss.19-23, 1995 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 122
Basım Tarihi: 1995
Doi Numarası: 10.1111/j.1601-5223.1995.00019.x
Dergi Adı: Hereditas
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.19-23
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

A 46,X,t(X;X) (qter --> p22::p22 --> qter) karyotype was found in the chromosome analysis of a 22 years old female patient with secondary amenorrhea. Further analysis with fluorescence in situ hybridization indicated that the marker chromosome had one active and one inactive centromere originating from the X chromosome. RBG-banding showed that the derivative X chromosome was preferentially inactivated in cultured lymphocytes.