Restless Leg Syndrome and Its Relationship with Parkinson's Disease

Kaynak D., Benbir G.

TURKISH JOURNAL OF NEUROLOGY, cilt.12, sa.2, ss.121-128, 2006 (ESCI, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2006
  • Dergi Adı: TURKISH JOURNAL OF NEUROLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.121-128
  • Anahtar Kelimeler: Restless legs syndrome, Parkinson's disease
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Scientific background: Restless legs syndrome (RLS) and Parkinson's disease (PD) exhibit striking similarities in impairment of central dopaminergic transmission and response to dopamine replacement strategies. The main question is whether RLS and PD are associated disorders sharing the common pathophsiology and genetic vulnerability or RLS resulted from nighttime motor disability related to disease itself or treatment or only a comorbidity. The links and also similarities and differences between RLS and PD in respect to epidemiology, clinical features, pathophysiology, neuropharmacology, neurophysiology, neuroimaging, iron metabolism and genetics were reported below.