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EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, pp.121-125, 2014 (SCI-Expanded, Scopus)
Objective: To investigate the diagnostic potential of anti-Mullerian hormone (AMH) in the differential diagnosis of various hyperandrogenemic conditions. Study design: Among 2241 consecutive women of reproductive age who were seen at a tertiary care university hospital with complaints of acne, hirsutism, androgenetic alopecia, and menstrual dysfunction (oligomenorrhea and/or amenorrhea), 107 patients with serum 17 alpha-hydroxyprogesterone (17 alpha-OHP) levels higher than 2 ng/ml were recruited for this study. An ACTH stimulation test was performed, and basal serum hormonal parameters and AMH levels were measured for all patients. Results: 25 patients were diagnosed with late-onset congenital adrenal hyperplasia (LOCAH), and 59 patients with polycystic ovary syndrome (PCOS) had significantly higher serum AMH levels than all other groups. Conclusion: Among hyperandrogenemic patients with serum 17 alpha-OHP levels >2 ng/ml, serum AMH levels might be introduced as a marker to be utilized clinically in the differential diagnosis of hyperandrogenemic patients, especially for identifying patients with PCOS. (C) 2014 Elsevier Ireland Ltd. All rights reserved.