Impact of the In Vitro Human Digestive Environment on the Interaction Between Vitamin C and Microplastics

Kilincer M., Saygin H., ÖZYÜREK M., Baysal A.

Analytical Letters, cilt.58, sa.12, ss.2087-2102, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 12
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1080/00032719.2024.2368021
  • Dergi Adı: Analytical Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.2087-2102
  • Anahtar Kelimeler: Ascorbic acid, digestion models, high-performance liquid chromatography-mass spectrometry (HPLC-MS), in vitro, microplastics, sorption, vitamin C
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Microplastics are present in the environment and living systems and bind with contaminants, proteins, and lipids. However, the interaction of vitamins with microplastics under in vitro conditions is unknown. Therefore, the aim of this study was to evaluate the interaction of vitamin C with microplastics obtained from food packages for simulated intestinal and gastric fluids. Sorption responses (kinetic and isotherm models) were examined using a batch technique with high-performance liquid chromatography-mass spectrometry (HPLC-MS). The results show that the sorption was achieved in 180 and 45 min for gastric and intestinal conditions. Vitamin C was adsorbed between 3 and 20% onto microplastics under in vitro digestive conditions. The sorption of vitamin C on microplastics conformed to the pseudo-second order (PSO) kinetic model. The isotherm models showed that sorption fitted the Temkin and Freundlich models.