Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
INTERNATIONAL JOURNAL OF NANOMEDICINE, vol.6, pp.311-320, 2011 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 6
- Publication Date: 2011
- Doi Number: 10.2147/ijn.s14309
- Journal Name: INTERNATIONAL JOURNAL OF NANOMEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.311-320
- Istanbul University-Cerrahpasa Affiliated: No
Abstract
Background: Nanosized dry powder inhalers provide higher stability for poorly water-soluble drugs as compared with liquid formulations. However, the respirable particles must have a diameter of 1-5 mu m in order to deposit in the lungs. Controlled agglomeration of the nanoparticles increases their geometric particle size so they can deposit easily in the lungs. In the lungs, they fall apart to reform nanoparticles, thus enhancing the dissolution rate of the drugs. Theophylline is a bronchodilator with poor solubility in water.