Postoperative radiotherapy in carcinoma of the cervix: treatment results and prognostic factors
Radiotherapy and Oncology, cilt.35, sa.3, ss.198-205, 1995 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 3
- Basım Tarihi: 1995
- Doi Numarası: 10.1016/0167-8140(95)01570-7
- Dergi Adı: Radiotherapy and Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.198-205
- Anahtar Kelimeler: POSTOPERATIVE RADIOTHERAPY, PROGNOSTIC FACTORS, CERVIX, UTERINE CERVIX, LOCAL-CONTROL, STAGE-IB, CANCER, IRRADIATION, HYSTERECTOMY, PATTERNS, SURGERY, FAILURE, TIME
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
In order to assess the role of postoperative radiotherapy and prognostic factors, 126 patients who were treated with radiotherapy after surgery for clinical early-stage carcinoma of the cervix were reviewed. All patients received external pelvic radiotherapy and 37 patients were treated with additional vaginal cuff irradiation. The 5-year overall survival, disease-free survival and locoregional control rates were 71.1,69.9 and 78.1%, respectively. The 5-year disease-free survival rates were 40% for grade 3 vs. 75.4% for grade 1 tumours (p = 0.05), 76.5% for pathological stage IB versus 54.1% for pathological stage IIA (p = 0.04), 36.6% for node-positive patients versus 82.5% for node-negative patients (p = 0.0017), 54% for full thickness cervical invasion versus 100% superficial cervical invasion (p = 0.01), 34.8% for positive margins versus 78.1 for negative margins (p < 0.0001). After a multivariate analysis, tumour grade (p = 0.026) and presence of positive margins (p = 0.006) were found to independently influence the outcome. Grade II and III complication rate was 5.5% in all patients. In conclusion, postoperative radiotherapy should be used in patients treated with simple hysterectomy as well as those treated with radical hysterectomy with unfavorable pathological findings. © 1995.